[Nov 2020] THEY CAN VACCINATE US THROUGH NASAL TEST SWABS AND TARGET THE BRAIN

YES, THEY CAN VACCINATE US THROUGH NASAL TEST SWABS AND TARGET THE BRAIN (BIOHACKING P.1)

by Silviu “Silview” Costinescu

by Silviu “Silview” Costinescu

I don’t know if they do it, because no independent researchers examine those swabs, but I have always pointed out that our overlords seem more concerned with testing than with vaccinating. Almost like the vaccines were the bait and tests were the switch. And now we also know they totally CAN do that. 
Just follow the science below.

UPDATE: LMAO, THIS WENT SO VIRAL VICE WAS SENT TO DEBUNK IT, SEE FOR YOURSELF, IT’S HILARIOUS!https://www.youtube.com/embed/SwqeIOvRfAQ?version=3&rel=1&showsearch=0&showinfo=1&iv_load_policy=1&fs=1&hl=en&autohide=2&wmode=transparent

Our comment has already been deleted, apparently, or I can’t find it anymore 

UPDATE: DR. LORRAINE DAY QUOTES AND FURTHER EXPLAINS THIS VERY ARTICLE!

https://video.wordpress.com/embed/4ldW7wUi?preloadContent=metadata&hd=1Share the video in higher resolution from our Bitchute or Lbry

November 3, 2020

RESEARCHERS ENGINEER TINY MACHINES THAT DELIVER MEDICINE EFFICIENTLY

by Johns Hopkins University School of Medicine

Johns Hopkins Researchers engineer tiny machines that deliver medicine efficiently
A theragripper is about the size of a speck of dust. This swab contains dozens of the tiny devices. Credit: Johns Hopkins University.

Inspired by a parasitic worm that digs its sharp teeth into its host’s intestines, Johns Hopkins researchers have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body.

David Gracias, Ph.D., a professor in the Johns Hopkins University Whiting School of Engineering, and Johns Hopkins gastroenterologist Florin M. Selaru, M.D., director of the Johns Hopkins Inflammatory Bowel Disease Center, led a team of researchers and biomedical engineers that designed and tested shape-changing microdevices that mimic the way the parasitic hookworm affixes itself to an organism’s intestines.

Made of metal and thin, shape-changing film and coated in a heat-sensitive paraffin wax, “theragrippers,” each roughly the size of a dust speck, potentially can carry any drug and release it gradually into the body.

The team published results of an animal study this week as the cover article in the journal Science Advances.

Gradual or extended release of a drug is a long-sought goal in medicine. Selaru explains that a problem with extended-release drugs is they often make their way entirely through the gastrointestinal tract before they’ve finished dispensing their medication.

“Normal constriction and relaxation of GI tract muscles make it impossible for extended-release drugs to stay in the intestine long enough for the patient to receive the full dose,” says Selaru, who has collaborated with Gracias for more than 10 years. “We’ve been working to solve this problem by designing these small drug carriers that can autonomously latch onto the intestinal mucosa and keep the drug load inside the GI tract for a desired duration of time.”

Researchers engineer tiny machines that deliver medicine efficiently
When an open theragripper, left, is exposed to internal body temperatures, it closes on the instestinal wall. In the gripper’s center is a space for a small dose of a drug. Credit: Johns Hopkins University

Thousands of theragrippers can be deployed in the GI tract. When the paraffin wax coating on the grippers reaches the temperature inside the body, the devices close autonomously and clamp onto the colonic wall. The closing action causes the tiny, six-pointed devices to dig into the mucosa and remain attached to the colon, where they are retained and release their medicine payloads gradually into the body. Eventually, the theragrippers lose their hold on the tissue and are cleared from the intestine via normal gastrointestinal muscular function.https://video.wordpress.com/embed/tZ71HjE1?preloadContent=metadata&hd=1Taken from the original research annexes

Gracias notes advances in the field of biomedical engineering in recent years.

“We have seen the introduction of dynamic, microfabricated smart devices that can be controlled by electrical or chemical signals,” he says. “But these grippers are so small that batteries, antennas and other components will not fit on them.”

Theragrippers, says Gracias, don’t rely on electricity, wireless signals or external controls. “Instead, they operate like small, compressed springs with a temperature-triggered coating on the devices that releases the stored energy autonomously at body temperature.”

The Johns Hopkins researchers fabricated the devices with about 6,000 theragrippers per 3-inch silicon wafer. In their animal experiments, they loaded a pain-relieving drug onto the grippers. The researchers’ studies found that the animals into which theragrippers were administered had higher concentrates of the pain reliever in their bloodstreams than did the control group. The drug stayed in the test subjects’ systems for nearly 12 hours versus two hours in the control group.https://www.youtube.com/embed/qN7Oj0oYy3g?version=3&rel=1&showsearch=0&showinfo=1&iv_load_policy=1&fs=1&hl=en&autohide=2&wmode=transparenthttps://www.youtube.com/embed/xQVBn6DWJwI?version=3&rel=1&showsearch=0&showinfo=1&iv_load_policy=1&fs=1&hl=en&autohide=2&wmode=transparent“Swarms of microscopic robots that can be injected”
Tell Melinda Gates we can inject robots these days.


At this point I just need to recall our October 2020 article: FACT-CHECKERS LIE: TEST SWABS REALLY LIKELY TO GIVE YOU THE “LEAKY BRAIN”

HERE’S A VERY SIMPLE WAY TO ATTACK THE BRAIN THROUGH THE TEST SWABS

I’ve seen a report on someone who had to undergo tests almost daily and he developed brain cancer over the course of about three months. But I can’t verify it, so that’s all it’s worth. However, the content of the video below can be verified by anyone.https://www.youtube.com/embed/_YEHPS9a2lU?version=3&rel=1&showsearch=0&showinfo=1&iv_load_policy=1&fs=1&hl=en&autohide=2&wmode=transparent

SPOOKY FIBERS IN MAKS AND TEST SWABS? WAIT ’TIL YOU READ THE SCIENCE!

Aaaand the last piece of the puzzle that we needed to get the picture. We may have missed many details, but we got the core idea right:

SOURCE

“Key to our findings is the demonstration that S1 promotes loss of barrier integrity in an advanced 3D microfluidic model of the human BBB, a platform that more closely resembles the physiological conditions at this CNS interface. Evidence provided suggests that the SARS-CoV-2 spike proteins trigger a pro-inflammatory response on brain endothelial cells that may contribute to an altered state of BBB function. Together, these results are the first to show the direct impact that the SARS-CoV-2 spike protein could have on brain endothelial cells; thereby offering a plausible explanation for the neurological consequences seen in COVID-19 patients.”

Check the follow ups in the Bio-hacking trilogy: 

RNA MODIFICATION USED TO ALTER DNA, BRAIN FUNCTIONS AND BEHAVIOR 
Part 3 went straight to video:
THE WALKING SERVERS. DON’T BE ONE, LEARN ABOUT DNA STORAGE, DNA PRIVACY AND BIOHACKING – DOCUMENTARY

Epub 2008 Dec 13.

NANOPARTICLES FOR NASAL VACCINATION

Noemi Csaba  1 Marcos Garcia-FuentesMaria Jose Alonso Affiliations

ABSTRACT

The great interest in mucosal vaccine delivery arises from the fact that mucosal surfaces represent the major site of entry for many pathogens. Among other mucosal sites, nasal delivery is especially attractive for immunization, as the nasal epithelium is characterized by relatively high permeability, low enzymatic activity and by the presence of an important number of immunocompetent cells. In addition to these advantageous characteristics, the nasal route could offer simplified and more cost-effective protocols for vaccination with improved patient compliance. The use of nanocarriers provides a suitable way for the nasal delivery of antigenic molecules. Besides improved protection and facilitated transport of the antigen, nanoparticulate delivery systems could also provide more effective antigen recognition by immune cells. These represent key factors in the optimal processing and presentation of the antigen, and therefore in the subsequent development of a suitable immune response. In this sense, the design of optimized vaccine nanocarriers offers a promising way for nasal mucosal vaccination.


SIMILAR ARTICLES

https://www.youtube.com/embed/0wFwXUhHu5c?version=3&rel=1&showsearch=0&showinfo=1&iv_load_policy=1&fs=1&hl=en&autohide=2&wmode=transparent2015 called…

PubMed, 2015 Jun 9.:

NANONEUROTHERAPEUTICS APPROACH INTENDED FOR DIRECT NOSE TO BRAIN DELIVERY

Shadab Md  1 Gulam Mustafa  2   3 Sanjula Baboota  3 Javed Ali  3Affiliations Expand

ABSTRACT

Context: Brain disorders remain the world’s leading cause of disability, and account for more hospitalizations and prolonged care than almost all other diseases combined. The majority of drugs, proteins and peptides do not readily permeate into brain due to the presence of the blood-brain barrier (BBB), thus impeding treatment of these conditions.

Objective: Attention has turned to developing novel and effective delivery systems to provide good bioavailability in the brain.

Methods: Intranasal administration is a non-invasive method of drug delivery that may bypass the BBB, allowing therapeutic substances direct access to the brain. However, intranasal administration produces quite low drug concentrations in the brain due limited nasal mucosal permeability and the harsh nasal cavity environment. Pre-clinical studies using encapsulation of drugs in nanoparticulate systems improved the nose to brain targeting and bioavailability in brain. However, the toxic effects of nanoparticles on brain function are unknown.

Result and conclusion: This review highlights the understanding of several brain diseases and the important pathophysiological mechanisms involved. The review discusses the role of nanotherapeutics in treating brain disorders via nose to brain delivery, the mechanisms of drug absorption across nasal mucosa to the brain, strategies to overcome the blood brain barrier, nanoformulation strategies for enhanced brain targeting via nasal route and neurotoxicity issues of nanoparticles.

CLICK

Epub 2013 Oct 16.

NANOEMULSION-BASED INTRANASAL DRUG DELIVERY SYSTEM OF SAQUINAVIR MESYLATE FOR BRAIN TARGETING

Hitendra S Mahajan  1 Milind S MahajanPankaj P NerkarAnshuman Agrawal Affiliations Expand

ABSTRACT

The central nervous system (CNS) is an immunological privileged sanctuary site-providing reservoir for HIV-1 virus. Current anti-HIV drugs, although effective in reducing plasma viral levels, cannot eradicate the virus completely from the body. The low permeability of anti-HIV drugs across the blood-brain barrier (BBB) leads to insufficient delivery. Therefore, developing a novel approaches enhancing the CNS delivery of anti-HIV drugs are required for the treatment of neuro-AIDS. The aim of this study was to develop intranasal nanoemulsion (NE) for enhanced bioavailability and CNS targeting of saquinavir mesylate (SQVM). SQVM is a protease inhibitor which is a poorly soluble drug widely used as antiretroviral drug, with oral bioavailability is about 4%. The spontaneous emulsification method was used to prepare drug-loaded o/w nanoemulsion, which was characterized by droplet size, zeta potential, pH, drug content. Moreover, ex-vivo permeation studies were performed using sheep nasal mucosa. The optimized NE showed a significant increase in drug permeation rate compared to the plain drug suspension (PDS). Cilia toxicity study on sheep nasal mucosa showed no significant adverse effect of SQVM-loaded NE. Results of in vivo biodistribution studies show higher drug concentration in brain after intranasal administration of NE than intravenous delivered PDS. The higher percentage of drug targeting efficiency (% DTE) and nose-to-brain drug direct transport percentage (% DTP) for optimized NE indicated effective CNS targeting of SQVM via intranasal route. Gamma scintigraphy imaging of the rat brain conclusively demonstrated transport of drug in the CNS at larger extent after intranasal administration as NE.

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https://youtube.com/watch?v=7WO5lPXuggk%3Fversion%3D3%26rel%3D1%26showsearch%3D0%26showinfo%3D1%26iv_load_policy%3D1%26fs%3D1%26hl%3Den%26autohide%3D2%26wmode%3Dtransparent

PubMed Epub, 2016 Jun 28:

HYDROGEL NANOPARTICLES AND NANOCOMPOSITES FOR NASAL DRUG/VACCINE DELIVERY

Sara Salatin  1   2 Jaleh Barar  1   3 Mohammad Barzegar-Jalali  3 Khosro Adibkia  3   4 Mitra Alami Milani  2   4 Mitra Jelvehgari  5   6Affiliations Expand

Affiliations

  • 1 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran.
  • 2 Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
  • 3 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Mailbox 51664, Tabriz, Iran.
  • 4 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 5 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Mailbox 51664, Tabriz, Iran. [email protected]
  • 6 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. [email protected]

ABSTRACT

Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intravenous administration. Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations. However, the rapid mucociliary clearance of the drug-loaded nanoparticles can cause a reduction in bioavailability percentage after intranasal administration. Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption. It is most certain that the high viscosity of hydrogel-based nanosystems can efficiently offer this mucoadhesive property. This update review discusses the possible benefits of using hydrogel polymer-based nanoparticles and hydrogel nanocomposites for drug/vaccine delivery through the intranasal administration.

Keywords: Brain; Hydrogel; Nanoparticles; Nasal delivery; Vaccine.https://www.youtube.com/embed/t0NFB0AzrwQ?version=3&rel=1&showsearch=0&showinfo=1&iv_load_policy=1&fs=1&hl=en&autohide=2&wmode=transparent

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Tagged

BIOHACKINGBLOOD BRAIN BARRIER

BRAIN DISORDERS

COVID19

DNA PRIVACY

HYDROGEL

NANOPARTICLES

NANOTECHNOLOGY

NASAL DELIVERY

NASAL SWABS

NASAL VACCINES

NEURODEGENERATIVE DISORDERS

NOSE TO BRAIN TARGETING

SWABS

TESTS

VACCINATIONS

VACCINE

VACCINES

By piotrbein

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